Sclerotherapy 

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Asclera® (polidocanol) Injection is a prescription medicine that is used in a procedure called sclerotherapy and administered by a healthcare provider to treat two types of veins in your legs.

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• Uncomplicated spider veins (very small varicose veins ≤ 1 mm in diameter)

• Uncomplicated small varicose veins (1 to 3 mm in diameter) known as reticular veins

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How often do I need treatment to see results?

The number and frequency of treatments depends on the size of the vessels and their location. Typically one to three treatments are expected.

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How does Asclera® work?

Asclera® is a sclerosing agent that is injected into the vein. It works by damaging the endothelium, the inside lining of blood vessels. This causes blood platelets and cellular debris to attach to the lining of the vessels. Eventually, cellular debris and platelets cause the blood vessel to clot. Over time, the clotted vein will be replaced with tissue.

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What should I expect after being treated with Asclera®?

Following treatment, you’ll need to wear waist-high compression stockings day and night for 2 to 3 days, then for 2 weeks during the day, as directed by your provider. Compression stockings are designed to apply pressure to your lower legs, helping to maintain blood flow, and reduce discomfort and swelling. Compression helps your legs heal and is necessary to reduce the risk of deep vein thrombosis. Please purchase these PRIOR to your first appointment. 

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You should also walk 15 to 20 minutes immediately after treatment and daily for a few days.

Are there activities I should avoid after receiving an Asclera® Injection?

For 2 to 3 days following the treatment, avoid:

• Heavy exercise

• Sunbathing

• Long plane flights

• Hot baths, hot tubs, or saunas

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Are there any possible side effects to Asclera® treatments?

Temporary side effects may occur at the site of the injection, including:

• Bruising

• Raised red areas

• Small skin sores

• Darkened skin in the form of lines or spots

• Multiple tiny red blood vessels

These side effects usually go away within a few days to several weeks. Some side effects may take months or years to resolve.

Although rare, some individuals may experience serious side effects, which may require treatment. These can include:

• An allergic reaction. Severe allergic reactions have been reported following polidocanol use, including anaphylactic reactions, some of them fatal. Severe reactions are most frequent with use of larger volumes (> 3 mL). The dose of polidocanol should therefore be minimized. A provider should be prepared to treat anaphylaxis appropriately

• In rare cases, formation of small “burns” or ulcers form, usually due to leakage of Asclera® into the skin. These will heal in time but may leave a scar

• Inadvertent perivascular injection of Asclera® can cause pain. If pain is severe, a local anesthetic (without adrenaline) may be injected

Is there any reason I should not be treated with Asclera®?

You should not be treated with Asclera® if you:

• Have a known allergy to polidocanol

• Have an acute vein or blood clotting (thromboembolic) disease

• Are pregnant or nursing

Be sure to tell your provider about all the medicines you are taking, including prescription and nonprescription medicines, vitamins and herbal products.

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